SOX9基因调控雄性哺乳动物生殖活动的研究进展

doi:10.11843/j.issn.0366-6964.2017.06.001

摘要/Abstract

摘要：

SRY-盒包含蛋白9（Sex determining region Y-box 9，SOX9）基因属于SRY-盒包含蛋白（SRY-type HMG box，SOX）基因家族中的重要成员，是继Y染色体性别决定基因（Sex-determining region of Y chromosome，SRY）后发现的又一重要的性别决定基因。近些年研究表明，SOX9基因在哺乳动物生殖活动中发挥着重要的调控作用，与性别分化、精子发生等生殖活动密切相关。本文主要从SOX9基因的结构特点和在胚胎期及生后哺乳动物生殖活动中的作用机制等方面的研究进展进行综述，旨在为进一步深入研究其在调控哺乳动物生殖活动中的分子作用机制及与其他基因的联合调控机制提供参考。

Abstract:

Sex determining region Y-box 9 (SOX9),an important member of the SRY-type HMG box (SOX) gene family, is another sex determination gene discovered after Sex-determining region of Y chromosome. Recent studies have shown that SOX9 gene plays an important role in the regulation of mammalian reproductive activity, and is closely related to sex differentiation and spermatogenesis. Some research progress in the structural characteristics of SOX9 gene and its function in regulating reproductive activity of mammals during the embryonic and postnatal development were reviewed, aiming to provide reference for further researching its molecular mechanisms in regulating reproductive activities alone or with other gene.

中图分类号:

Q344⁺.1

李讨讨, 马友记, 赵兴绪. SOX9基因调控雄性哺乳动物生殖活动的研究进展[J]. 畜牧兽医学报, 2017, 48(6): 971-978.

LI Tao-tao, MA You-ji, ZHAO Xing-xu. Research Progress on Reproduction Regulation of SOX9 Gene in Male Mammals[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2017, 48(6): 971-978.

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